Every Hour of Delay of
Appropriate Antimicrobial
Treatment Increases Morbidity
and Mortality Associated with Sepsis4

Sepsis

Sepsis is the most deadly and costly hospital condition to treat today1
  • Over 1.6M are diagnosed with sepsis and over 250,000 die each year in the US1
  • Approximately $24 Billion spent annually at an average cost per hospital stay of $18,4001
  • Survivors risk physical and cognitive impairment and more-than-doubled the risk of dying within 5 years2

Challenges in Sepsis Diagnosis

Reducing time to appropriate antimicrobial treatment improves outcomes1
  • 80% of sepsis deaths could be prevented with rapid diagnosis and treatment1
  • Diagnosis today is a multi-step process that takes 1 to 5 days to pathogen ID and appropriate or optimal antimicrobial therapy3
  • 30%-45% of sepsis patients receive inappropriate initial antimicrobial therapy4,5
  • Every hour delay of appropriate antimicrobial treatment increases morbidity and mortality associated with sepsis4

 
 

1Kumar et al. (2015). Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance. Curr Infect Dis Rep.,17(7), 493.

2Derek C. Angus, M.D., M.P.H., and Tom van der Poll, M.D., Ph.D., (2013), Severe Sepsis and Septic Shock, N Engl J Med 2013; 369:840-851.

3Konrad Reinhart et al, (2012). New Approaches to Sepsis: Molecular Diagnostics and Biomarkers. Clin Microbiol Rev. 2012 Oct; 25(4): 609–634.

4Sepsis Alliance (2016, November) Sepsis 2016 fact sheet Retrieved from https://www.sepsis.org/downloads/2016_sepsis_facts_media.pdf

5Opota, O., Jaton, K., & Greub, G. (2015). Microbial diagnosis of bloodstream infection: towards molecular diagnosis directly from blood. Clinical Microbiology And Infection, 21(4), 323-331.