Incidence of sepsis worldwide3


Spent per yr on sepsis in the US4


Receive inappropriate antimicrobial therapy12


Increase in mortality for a 6 hour delay in appropriate therapy5

Sepsis causes 1 death every 3-4 seconds2


In the next 5 minutes, approximately 75 people will die of sepsis globally2

  • Sepsis is one of the leading causes of death globally6
  • In the Western world 7,8, sepsis is one of the most expensive conditions
  • 15-40% of patients receive inappropriate initial antimicrobial therapy12
  • Speed counts – results in minutes vs. hours offers the potential to tailor initial antimicrobial therapy, which has shown to improve outcomes5
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Designed for rapid detection of over 90% of pathogens causing BSI in minutes, not hours or days

  • Surviving Sepsis Campaign (SSC)10 and UK National Institute for Health and Care Excellence (NICE)11 guidelines call for antimicrobial therapy within 1 hour of diagnosis of sepsis
  • Every hour of delay in appropriate initial antibiotic therapy increases mortality by 7.6% associated with severe sepsis5
  • Designed for detection of mono- or poly-microbial bloodstream infections in less than an hour
  • Results reported as 16 individual test results at either the family, genus or species level
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1Sepsis Alliance (2016, November) Sepsis 2016 fact sheet Retrieved from https://www.sepsis.org/downloads/2016_sepsis_facts_media.pdf

2Dugani, S., Laxminarayan, R., & Kissoon, N. (2017). The quadruple burden of sepsis. Canadian Medical Association Journal, 189 (36), E1128-E1129.

3Fleischmann C. et al. (2016). Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations, Am J Respir Crit Care Med, 1;193(3), 259-72.

4National Inpatient Hospital Costs: The Most Expensive Conditions by Payer, 2013 (MAY 2016) HCUP Statistical Brief #204 Retrieved from https://www.hcup-us.ahrq.gov/reports/statbriefs/sb204-Most-Expensive-Hospital-Conditions.pdf

5Kumar et al. (2015). Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance. Curr Infect Dis Rep.,17(7), 493.

6Global Sepsis Alliance (2015, September) Retrieved from http://www.wfpiccs.org/wp-content/uploads/2015/09/2015_WSD_FactSheet_long_English.pdf

7European Commission: CORDIS: Projects and Results: Next generation sepsis diagnosis. (2016) Retrieved from Cordis.europa.eu. http://cordis.europa.eu/project/rcn/199396_en.html

8National Inpatient Hospital Costs: The Most Expensive Conditions by Payer, 2013 #204. (2016, May) Retrieved from Hcup-us.ahrq.gov. https://www.hcup-us.ahrq.gov/reports/statbriefs/sb204-Most-Expensive-Hospital-Conditions.jsp

9Lueangarun, S. & Leelarasamee, A. (2012). Impact of Inappropriate Empiric Antimicrobial Therapy on Mortality of Septic Patients with Bacteremia: A Retrospective Study. Interdisciplinary Perspectives on Infectious Diseases, Volume 2012, Article ID 765205, 13.

10Andrew Rhodes et al. (2017). Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock, Crit Care Med, 45(3), 486-552.

11National Institute for Health and Care Excellence Nice.org.uk (2017, September) Retrieved from https://www.nice.org.uk/guidance/qs161/chapter/Quality-statements

12McDonald et.al. (2005).Risk Factors for Ineffective Therapy in Patients with Bloodstream Infection, Arch Intern Med. 2005; 165308-313